droxidopa - CISMeF

Preferred Label : droxidopa;

MeSH definition : A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995); A synthetic precursor of norepinephrine that is used in the treatment of PARKINSONIAN DISORDERS and ORTHOSTATIC HYPOTENSION.;

MeSH synonym : 3,4-threo-dops; 3,4 threo dops; threo dops; threo-dops; dl-threo-3,4-dihydroxyphenylserine; dl threo 3,4 dihydroxyphenylserine;

MeSH Hyperonym : 3,4-Dihydroxyphenylserine; 3,4 Dihydroxyphenylserine;

Related MeSH term : erythro-3,4-Dihydroxyphenylserine; droxidopa, (DL-Tyr)-Isomer; erythro 3,4 Dihydroxyphenylserine;

MeSH CAS label : L-Tyrosine, beta,3-dihydroxy-, threo-;

MeSH Related Number : droxidopa, (DL-Tyr)-Isomer; 13147-26-7 ((DL-Tyr)-isomer); 23651-95-8 (Droxidopa);

Registry Number MeSH : 23651-95-8;

Related CAS MeSH : 13147-26-7 (Droxidopa, (DL-Tyr)-Isomer);

Wikipedia link : https://en.wikipedia.org/wiki/Droxidopa;

Is substance : O;

UNII : J7A92W69L7;

InChIKey : QXWYKJLNLSIPIN-JGVFFNPUSA-N;

Details

Origin ID

D015103;

UMLS CUI

C0000378;

ATC code(s)
- droxidopa [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Droxidopa [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Droxidopa [NCIt concept]
- Droxidopa (substance) [SNOMED CT concept]
Pharmacological action(s)
- antiparkinson agents [MeSH Descriptor]
Record concept(s)
- 3,4-Dihydroxyphenylserine [MeSH concept]
- droxidopa [MeSH concept]
- droxidopa, (DL-Tyr)-Isomer [MeSH concept]
- erythro-3,4-Dihydroxyphenylserine [MeSH concept]
Related MeSH Supplementary Concept(s)
- 3-(3,4-dihydroxyphenyl)-N-methylserine [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing droxidopa (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Droxidopa [NCIt concept]
- Droxidopa (substance) [SNOMED CT concept]
- Product containing droxidopa (medicinal product) [SNOMED CT concept]
- droxidopa [ATC Code]
Validated automatic mappings to BTNT
- droxidopa [ATC Code]

Keyword's position in hierarchy(ies) :

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