MeSH definition : Drugs that inhibit the transport of neurotransmitters into axon terminals or into
storage vesicles within terminals. For many transmitters, uptake determines the time
course of transmitter action so inhibiting uptake prolongs the activity of the transmitter.
Blocking uptake may also deplete available transmitter stores. Many clinically important
drugs are uptake inhibitors although the indirect reactions of the brain rather than
the acute block of uptake itself is often responsible for the therapeutic effects.;
MeSH annotation : GEN or unspecified; prefer specific groups or specific drugs; coord IM with specific
neurotransmitters /physiol (IM); DF: NEUROTRANSM UPTAKE INHIB; general or unspecified; prefer specific groups or specific drugs; coordinate with
specific neurotransmitters /physiol;
Drugs that inhibit the transport of neurotransmitters into axon terminals or into
storage vesicles within terminals. For many transmitters, uptake determines the time
course of transmitter action so inhibiting uptake prolongs the activity of the transmitter.
Blocking uptake may also deplete available transmitter stores. Many clinically important
drugs are uptake inhibitors although the indirect reactions of the brain rather than
the acute block of uptake itself is often responsible for the therapeutic effects.
Allowable qualifiers