tosylphenylalanyl chloromethyl ketone

Preferred Label : tosylphenylalanyl chloromethyl ketone;

MeSH definition : An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.;

MeSH synonym : ketone, tosylphenylalanyl chloromethyl; chloromethyl ketone, tosylphenylalanyl; tosylphenylalanyl chloromethane; chloromethane, tosylphenylalanyl; tpck; chlorophenyltosylamidobutanone;

CISMeF synonym : l-chloromethyl (2-phenyl-1-(p-toluenesulphonylamino)ethyl) ketone;

MeSH CAS label : benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-;

Registry Number MeSH : 402-71-1;

Codes EINECS : 206-954-6;

Is substance : O;

Details

Origin ID

D014108;

UMLS CUI

C0040498;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- l-chloromethyl (2-phenyl-1-(p-toluenesulphonylamino)ethyl) ketone [Substance BNPC]
Pharmacological action(s)
- alkylating agents [MeSH Descriptor]
- protein synthesis inhibitors [MeSH Descriptor]
- serine proteinase inhibitors [MeSH Descriptor]
Record concept(s)
- tosylphenylalanyl chloromethyl ketone [MeSH concept]
Related MeSH Supplementary Concept(s)
- tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- l-chloromethyl (2-phenyl-1-(p-toluenesulphonylamino)ethyl) ketone [Substance BNPC]

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