tetanus toxin - CISMeF

Preferred Label : tetanus toxin;

MeSH definition : Protein synthesized by CLOSTRIDIUM TETANI as a single chain of 150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.;

MeSH synonym : toxins, tetanus; toxin, tetanus; clostridium tetani toxin; toxin, clostridium tetani; tetanus toxins;

MeSH hyponym : clostridial neurotoxin; Neurotoxin, Clostridial;

MeSH annotation : /antag permitted but consider also TETANUS ANTITOXIN;

Wikipedia link : https://en.wikipedia.org/wiki/Tetanus toxin;

Is substance : O;

Details

Origin ID

D013744;

UMLS CUI

C0039617;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Clostridium tetani Toxin [NCIt concept]
- Clostridium tetani toxin [LOINC component]
- Clostridium tetani toxin (substance) [SNOMED CT concept]
- clostridium tetani toxin [SNOMED Notion]
Indexing information
- 3-(2-amino-1-sulfanylethyl)benzenesulfonamide [MeSH Supplementary Concept]
- TNTCFP protein [MeSH Supplementary Concept]
- tetanus toxin receptor [MeSH Supplementary Concept]
Pharmacological action(s)
- neurotoxins [MeSH Descriptor]
Record concept(s)
- clostridial neurotoxin [MeSH concept]
- tetanus toxin [MeSH concept]
Related MeSH Supplementary Concept(s)
- P30 tetanus toxin peptide [MeSH Supplementary Concept]
- azo-GnRH tetanus toxoid conjugate [MeSH Supplementary Concept]
- tetanolysin [MeSH Supplementary Concept]
- tetanospasmin [MeSH Supplementary Concept]
- tetanus toxin (947-966) [MeSH Supplementary Concept]
- tetanus toxin fragment BIIb [MeSH Supplementary Concept]
- tetanus toxin fragment C [MeSH Supplementary Concept]
- zinc-endopeptidase, tetanus neurotoxin [MeSH Supplementary Concept]
See also
- clostridium tetani [MeSH Descriptor]
- tetanus antitoxin [MeSH Descriptor]
See also (suggested by CISMeF)
- tetanus [MeSH Descriptor]
See also inter- (CISMeF)
- Tetanus vaccine (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hazardous or Poisonous Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clostridium tetani Toxin [NCIt concept]
- Clostridium tetani toxin [LOINC component]
- Clostridium tetani toxin (substance) [SNOMED CT concept]
- clostridium tetani toxin [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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