transglutaminases

Preferred Label : transglutaminases;

MeSH definition : Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.;

MeSH synonym : glutaminyl peptide gamma glutamyltransferases; glutaminyl-peptide gamma-glutamyltransferases; protein-glutamine gamma-glutamyltransferases; gamma-glutamyltransferases, protein-glutamine; protein glutamine gamma glutamyltransferases; gamma-glutamyltransferases, glutaminyl-peptide; Transglutaminase;

MeSH CAS label : protein-glutamine:amine gamma-glutamyltransferase;

MeSH Related Number : 80146-85-6 (CAS RN);

Registry Number MeSH : EC 2.3.2.13;

MeSH annotation : distinguish X refs GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available; distinguish entry terms GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES, and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available;

Wikipedia link : https://en.wikipedia.org/wiki/Transglutaminases;

Is substance : O;

UNII : EC 2.3.2.13;

Details

Origin ID

D011503;

UMLS CUI

C0033679;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Proteinglutamine gamma-glutamyltransferase (substance) [SNOMED CT concept]
- Transglutaminase [NCIt concept]
- protein-glutamine gamma-glutamyltransferase activity [GO term]
- proteinglutamine gamma-glutamyltransferase [SNOMED Notion]
Indexing information
- 1,3,4,5-tetramethyl-2-((2-oxopropyl)thio)imidazolium [MeSH Supplementary Concept]
- 1,3-dimethyl-2-((2-oxopropyl)thio)imidazolium [MeSH Supplementary Concept]
- 1,3-dimethyl-4,5-diphenyl-22(oxopropyl)thioimidazolium trifluoromethylsulfonate [MeSH Supplementary Concept]
- 1-(2-aminoethyl)-3-phenylthiourea [MeSH Supplementary Concept]
- 1-(5-aminopentyl)-3-phenylthiourea [MeSH Supplementary Concept]
- BJJF078 [MeSH Supplementary Concept]
- ERW1041E [MeSH Supplementary Concept]
- RS 48373 [MeSH Supplementary Concept]
- XPC protein, human [MeSH Supplementary Concept]
- monodansylcadaverine [MeSH Supplementary Concept]
- monodansylthiacadaverine [MeSH Supplementary Concept]
- tridegin [MeSH Supplementary Concept]
Record concept(s)
- transglutaminases [MeSH concept]
Related MeSH Supplementary Concept(s)
- Galphah protein, human [MeSH Supplementary Concept]
- RAD4 protein, S pombe [MeSH Supplementary Concept]
- TGM3 protein, human [MeSH Supplementary Concept]
- TGM6 protein, human [MeSH Supplementary Concept]
- Tg protein, Drosophila [MeSH Supplementary Concept]
- Tgm3 protein, mouse [MeSH Supplementary Concept]
- dermonecrotic toxin, Bordetella [MeSH Supplementary Concept]
- ghalpha protein, rat [MeSH Supplementary Concept]
- transglutaminase 1 [MeSH Supplementary Concept]
- transglutaminase 4 [MeSH Supplementary Concept]
- transglutaminase 5 [MeSH Supplementary Concept]
- transglutaminase NI [MeSH Supplementary Concept]
- transglutaminase NII [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Proteinglutamine gamma-glutamyltransferase (substance) [SNOMED CT concept]
- Transglutaminase [NCIt concept]
- proteinglutamine gamma-glutamyltransferase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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