Preferred Label : properdin;

MeSH definition : A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.;

MeSH synonym : factor p, complement; Complement Factor P;

MeSH CAS label : complement factor p;

Registry Number MeSH : 11016-39-0;

Wikipedia link : https://en.wikipedia.org/wiki/Properdin;

Is substance : O;

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A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.

http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=2966
France
French
rare diseases
properdin
immunologic deficiency syndromes
scientific and technical information

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25/07/2025


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