properdin - CISMeF

Preferred Label : properdin;

MeSH definition : A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.;

MeSH synonym : factor p, complement; Complement Factor P;

MeSH CAS label : complement factor p;

Registry Number MeSH : 11016-39-0;

Wikipedia link : https://en.wikipedia.org/wiki/Properdin;

Is substance : O;

Details

Origin ID

D011414;

UMLS CUI

C0033452;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Pharmacological action(s)
- immunologic factors [MeSH Descriptor]
Record concept(s)
- properdin [MeSH concept]
Related MeSH Supplementary Concept(s)
- peptide P (properdin) [MeSH Supplementary Concept]
- properdin deficiency, X-linked [MeSH Supplementary Concept]
- properdin deficiency, type II [MeSH Supplementary Concept]
- properdin deficiency, type III [MeSH Supplementary Concept]
- properdistatin [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Complement factor P [LOINC component]
- Properdin (substance) [SNOMED CT concept]
- properdin, nos [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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