Preferred Label : proinsulin;
MeSH definition : A pancreatic polypeptide of about 110 amino acids, depending on the species, that
is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is
comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting
C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two
between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide
are the secreted products. Intact proinsulin with low bioactivity also is secreted
in small amounts.;
MeSH CAS label : proinsulin;
Registry Number MeSH : 9035-68-1;
Wikipedia link : https://en.wikipedia.org/wiki/Proinsulin;
Is substance : O;
Origin ID : D011384;
UMLS CUI : C0033362;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
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- Semantic type(s)
- UMLS correspondences (same concept)
A pancreatic polypeptide of about 110 amino acids, depending on the species, that
is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is
comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting
C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two
between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide
are the secreted products. Intact proinsulin with low bioactivity also is secreted
in small amounts.
