pregnancy-associated plasma protein-a

Preferred Label : pregnancy-associated plasma protein-a;

MeSH definition : A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.;

MeSH synonym : igfbp 4 metalloproteinase; igfbp 4 protease; igfbp-4 protease; igfbp-4-specific proteinase; insulin like growth factor dependent igf binding protein 4 protease; insulin-like growth factor-dependent igf binding protein-4 protease; insulin-like-growth factor binding protein-4 protease; papp-a; papp-alpha; pregnancy-associated alpha-plasma protein; protease, igfbp-4; metalloproteinase, igfbp-4; insulin like growth factor binding protein 4 protease; papp alpha; pregnancy associated alpha plasma protein; igfbp-4 metalloproteinase; pregnancy associated plasma protein A;

Registry Number MeSH : EC 3.4.24.-;

Wikipedia link : https://en.wikipedia.org/wiki/Pregnancy-associated plasma protein-a;

Is substance : O;

Details

Origin ID

D011266;

UMLS CUI

C0032999;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Amelia, posterior, with pelvic and pulmonary hypoplasia syndrome [OMIM Phenotype]
- Disability Assessment for Dementia Questionnaire [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 15 [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 8 [NCIt concept]
- GLI3 wt Allele [NCIt concept]
- PAPPA Gene [NCIt concept]
- PAPPA wt Allele [NCIt concept]
- PSTPIP1 wt Allele [NCIt concept]
- Pappalysin 1 [OMIM gene]
- Poly(A) Polymerase Alpha [NCIt concept]
- Polydactyly, postaxial, type a1 [OMIM Phenotype]
- Pyogenic sterile arthritis, pyoderma gangrenosum, and acne [OMIM Phenotype]
- pappalysin 1 [HGNC gene]
Record concept(s)
- Pregnancy-Associated plasma Protein-A [MeSH concept]
Related MeSH Supplementary Concept(s)
- PAPPA protein, human [MeSH Supplementary Concept]
- PAPPA2 protein, human [MeSH Supplementary Concept]
- PAPPA2 protein, mouse [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Pregnancy-Associated Plasma Protein-A Measurement [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Pregnancy associated plasma protein A [LOINC component]
- Pregnancy associated plasma protein A (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients