methylenetetrahydrofolate dehydrogenase (NADP)

Preferred Label : methylenetetrahydrofolate dehydrogenase (NADP);

MeSH definition : An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.;

MeSH synonym : methylenetetrahydrofolate dehydrogenase; dehydrogenase, methylenetetrahydrofolate; methylenetetrahydrofolate dehydrogenase (NADP );

MeSH CAS label : 5,10-Methylenetetrahydrofolate:NADP oxidoreductase;

Registry Number MeSH : EC 1.5.1.5;

MeSH annotation : do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD );

Is substance : O;

UNII : EC 1.5.1.5;

Details

Origin ID

D008754;

UMLS CUI

C0025756;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 5,6,7,8-tetrahydro-N(5),N(10)-carbonylfolic acid [MeSH Supplementary Concept]
Record concept(s)
- methylenetetrahydrofolate dehydrogenase (NADP) [MeSH concept]
Related MeSH Supplementary Concept(s)
- MTHFD1 protein, Arabidopsis [MeSH Supplementary Concept]
- MTHFD1 protein, human [MeSH Supplementary Concept]
- MTHFD2 protein, human [MeSH Supplementary Concept]
- MTHFD2L protein, human [MeSH Supplementary Concept]
- Mthfd1 protein, mouse [MeSH Supplementary Concept]
- Mthfd2 protein, mouse [MeSH Supplementary Concept]
- formyl-methenyl-methylenetetrahydrofolate synthetase [MeSH Supplementary Concept]
- methylene tetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase [MeSH Supplementary Concept]
See also
- formate-tetrahydrofolate ligase [MeSH Descriptor]
- methenyltetrahydrofolate cyclohydrolase [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Methylenetetrahydrofolate dehydrogenase (nicotinamide adenine dinucleotide phosphate ^+^) (substance) [SNOMED CT concept]
- Methylenetetrahydrofolate dehydrogenase NADP [LOINC component]
- methylenetetrahydrofolate dehydrogenase (nadp+) [SNOMED Notion]

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