glucosylceramidase

Preferred Label : glucosylceramidase;

MeSH definition : A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.;

MeSH synonym : glucocerebrosidase; beta glucocerebrosidase; hydrolase, glucosylsphingosine glucosyl; beta-glucosidase, glucosylceramide; glucosylceramide beta-glucosidase; glucosylsphingosine glucosyl hydrolase; glucosyl hydrolase, glucosylsphingosine; acid beta-glucosidase; acid beta glucosidase; beta-glucosidase, acid; beta-glucocerebrosidase; glucocerebroside beta-glucosidase; glucocerebroside beta glucosidase; beta-glucosidase, glucocerebroside; glucosyl ceramidase; ceramidase, glucosyl; glucosylceramide beta glucosidase;

MeSH CAS label : D-Glucosyl-N-acylsphingosine glucosylhydrolase;

Registry Number MeSH : EC 3.2.1.45;

MeSH annotation : /defic: consider also GAUCHER DISEASE;

Wikipedia link : https://en.wikipedia.org/wiki/Glucosylceramidase;

Is substance : O;

UNII : EC 3.2.1.45;

Details

Origin ID

D005962;

UMLS CUI

C0017768;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 2-deoxy-2-fluoroglucopyranosyl fluoride [MeSH Supplementary Concept]
- 5-N,6-O-(N''-octyliminomethylidene)nojirimycin [MeSH Supplementary Concept]
- 5-N,6-S-(N''-4'-(adamantane-1-carbonylamino)butyliminomethylidene)-6-thionojirimycin [MeSH Supplementary Concept]
- 6-bromoconduritol [MeSH Supplementary Concept]
- N-octyl-beta-valienamine [MeSH Supplementary Concept]
- bromoconduritol-B-epoxide [MeSH Supplementary Concept]
- castanospermine [MeSH Supplementary Concept]
- conduritol epoxide [MeSH Supplementary Concept]
Record concept(s)
- glucosylceramidase [MeSH concept]
Related MeSH Supplementary Concept(s)
- Abcertin [MeSH Supplementary Concept]
- GBA protein, human [MeSH Supplementary Concept]
- GBA2 protein, human [MeSH Supplementary Concept]
- Gba protein, mouse [MeSH Supplementary Concept]
- Gba1b protein, Drosophila [MeSH Supplementary Concept]
- alglucerase [MeSH Supplementary Concept]
- gba protein, zebrafish [MeSH Supplementary Concept]
- imiglucerase [MeSH Supplementary Concept]
- taliglucerase alfa [MeSH Supplementary Concept]
- velaglucerase alfa, human [MeSH Supplementary Concept]
See also
- gaucher disease [MeSH Descriptor]
See also inter- (CISMeF)
- Glucosidase, beta, acid [OMIM gene]
- glucosylceramidase beta 1 [ORDO Gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Acid beta glucosidase [OBSOLETE LOINC component]
- Glucosylceramidase [LOINC component]
- Glucosylceramidase (substance) [SNOMED CT concept]
- Lysosomal Acid Glucosylceramidase [NCIt concept]
- glucosylceramidase [SNOMED Notion]

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