glucose-6-phosphate isomerase

Preferred Label : glucose-6-phosphate isomerase;

MeSH definition : An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.;

MeSH synonym : isomerase, glucosephosphate; phosphoglucose isomerase; isomerase, glucose 6 phosphate; isomerase, phosphohexose; phosphohexose isomerase; glucosephosphate isomerase; isomerase, glucose-6-phosphate; isomerase, phosphoglucose; glucose 6 phosphate isomerase;

MeSH hyponym : autocrine motility factor; Motility Factor, Autocrine; Tumor Autocrine Motility Factor; Tumor-Cell Autocrine Motility Factor; Tumor Cell Autocrine Motility Factor; Neuroleukin; Factor, Autocrine Motility;

MeSH CAS label : D-Glucose-6-phosphate ketol-isomerase;

MeSH Related Number : autocrine motility factor; EC 5.3.1.9;

Registry Number MeSH : EC 5.3.1.9;

Related CAS MeSH : EC 5.3.1.9 (Autocrine motility factor);

Wikipedia link : https://en.wikipedia.org/wiki/Glucose-6-phosphate isomerase;

Is substance : O;

UNII : EC 5.3.1.9;

Details

Origin ID

D005956;

UMLS CUI

C0017759;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Glucose-6-phosphate isomerase [OMIM gene]
- glucose-6-phosphate isomerase [ORDO Gene]
- glucose-6-phosphate isomerase [HGNC gene]
Indexing information
- 3-deoxy-3-C-methylene-ribo-hexose-6-phosphate [MeSH Supplementary Concept]
- arabinonate-5-phosphate [MeSH Supplementary Concept]
Record concept(s)
- Glucose-6-Phosphate isomerase [MeSH concept]
- autocrine motility factor [MeSH concept]
Related MeSH Supplementary Concept(s)
- 3-hexulose-6-phosphate isomerase [MeSH Supplementary Concept]
- GPI protein, human [MeSH Supplementary Concept]
- Gpi1 protein, mouse [MeSH Supplementary Concept]
- gpi protein, rat [MeSH Supplementary Concept]
- pgi protein, E coli [MeSH Supplementary Concept]
Related MeSH term(s)
- anemia, hemolytic, congenital nonspherocytic [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Glucose phosphate isomerase [LOINC component]
- Glucose-6-phosphate isomerase (substance) [SNOMED CT concept]
- glucose-6-phosphate isomerase [SNOMED Notion]

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