Preferred Label : factor XII;
MeSH definition : Stable blood coagulation factor activated by contact with the subendothelial surface
of an injured vessel. Along with prekallikrein, it serves as the contact factor that
initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor
XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased
incidence of thromboembolic disease. Mutations in the gene for factor XII that appear
to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA
TYPE III.;
MeSH synonym : coagulation factor xii; hageman factor; Factor Twelve; Factor 12;
CISMeF synonym : blood coagulation factorxi; factor xii, coagulation; xii, coagulation factor; coagulation factorxi, blood; factorxi, blood coagulation;
MeSH CAS label : blood-coagulation factor XII;
Registry Number MeSH : 9001-30-3;
Wikipedia link : https://en.wikipedia.org/wiki/Factor 12;
Is substance : O;
Origin ID : D005174;
UMLS CUI : C0015525;
Allowable qualifiers
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- UMLS correspondences (same concept)
Stable blood coagulation factor activated by contact with the subendothelial surface
of an injured vessel. Along with prekallikrein, it serves as the contact factor that
initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor
XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased
incidence of thromboembolic disease. Mutations in the gene for factor XII that appear
to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA
TYPE III.
