Preferred Label : DNA, satellite;
MeSH definition : Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres.
They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated
in tandem many times to form large blocks of sequence. Additionally, following the
accumulation of mutations, these blocks of repeats have been repeated in tandem themselves.
The degree of repetition is on the order of 1000 to 10 million at each locus. Loci
are few, usually one or two per chromosome. They were called satellites since in density
gradients, they often sediment as distinct, satellite bands separate from the bulk
of genomic DNA owing to a distinct BASE COMPOSITION.;
MeSH synonym : satellite dna; satellite dnas; dnas, satellite;
MeSH hyponym : satellite I DNA; DNA, Satellite I; DNAs, Satellite I; I DNA, Satellite; I DNAs, Satellite; Satellite I DNAs;
Is substance : O;
Origin ID : D004276;
UMLS CUI : C0012934;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Record concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres.
They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated
in tandem many times to form large blocks of sequence. Additionally, following the
accumulation of mutations, these blocks of repeats have been repeated in tandem themselves.
The degree of repetition is on the order of 1000 to 10 million at each locus. Loci
are few, usually one or two per chromosome. They were called satellites since in density
gradients, they often sediment as distinct, satellite bands separate from the bulk
of genomic DNA owing to a distinct BASE COMPOSITION.
