DNA polymerase II

Preferred Label : DNA polymerase II;

MeSH definition : A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents. EC 2.7.7.7.; A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents.;

MeSH synonym : dna dependent dna polymerase ii; dna polymerase epsilon; dna-dependent dna polymerase ii; DNA pol II;

CISMeF synonym : pol ii; polymerase epsilon, dna; polymerase ii, dna;

Registry Number MeSH : EC 2.7.7.-;

Is substance : O;

UNII : EC 2.7.7.7;

Details

Origin ID

D004257;

UMLS CUI

C0012889;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- DNA-directed DNA Polymerase [NCIt concept]
- DNA-directed DNA polymerase activity [GO term]
- Nucleotidyltransferase [NCIt concept]
- POL Gene [NCIt concept]
- Poland [NCIt concept]
- Polymerase, dna, epsilon [OMIM gene]
False automatic mappings
- RNA Polymerase II [NCIt concept]
Indexing information
- 1-(2-deoxy-2-methylene-erthyro-pentofuranosyl)cytosine 5'-triphosphate [MeSH Supplementary Concept]
- 3-deoxyaphidicolin [MeSH Supplementary Concept]
- DPB2 protein, arabidopsis [MeSH Supplementary Concept]
- N(2)-(4-n-butylphenyl) 2'-deoxyguanosine [MeSH Supplementary Concept]
- N(2)-(4-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate [MeSH Supplementary Concept]
- NSC 612567 [MeSH Supplementary Concept]
- NSC 613060 [MeSH Supplementary Concept]
- PHYLPA 18 [MeSH Supplementary Concept]
- acyclovir triphosphate [MeSH Supplementary Concept]
- kelletinin A [MeSH Supplementary Concept]
- kelletinin I [MeSH Supplementary Concept]
- polB protein, E coli [MeSH Supplementary Concept]
Record concept(s)
- DNA polymerase II [MeSH concept]
Related MeSH Supplementary Concept(s)
- DPB3-1 protein, Arabidopsis [MeSH Supplementary Concept]
- Dpb2 protein, S cerevisiae [MeSH Supplementary Concept]
- Dpb3 protein, S pombe [MeSH Supplementary Concept]
- Dpb4 protein, S pombe [MeSH Supplementary Concept]
- POL2a protein, arabidopsis [MeSH Supplementary Concept]
- POL2b protein, arabidopsis [MeSH Supplementary Concept]
- POLE protein, human [MeSH Supplementary Concept]
- POLE2 protein, human [MeSH Supplementary Concept]
- pole protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients