Preferred Label : dianhydrogalactitol;
MeSH definition : One of the cytotoxic dihalohexitols that may have alkylating antineoplastic activity.
It causes bone marrow toxicity. The active form is thought to be the diepoxide.; One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide
group during all phases of the cell cycle, resulting in a disruption of DNA function
and cell cycle arrest. It has antineoplastic activity and also causes bone marrow
toxicity.;
MeSH synonym : 1,2,5,6-dianhydrogalactitol; diepoxydulcitol; dianhydrodulcitol; diepoxygalactitol; 1,2-5,6-Dianhydrogalactitol;
MeSH hyponym : NSC-132313; NSC 132313; NSC132313;
MeSH CAS label : galactitol, 1,2:5,6-dianhydro-;
MeSH Related Number : 23261-20-3 (Dianhydrogalactitol);
Registry Number MeSH : 23261-20-3;
Is substance : O;
UNII : 4S465RYF7M;
Origin ID : D003961;
UMLS CUI : C0011967;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
One of the cytotoxic dihalohexitols that may have alkylating antineoplastic activity.
It causes bone marrow toxicity. The active form is thought to be the diepoxide.
One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide
group during all phases of the cell cycle, resulting in a disruption of DNA function
and cell cycle arrest. It has antineoplastic activity and also causes bone marrow
toxicity.
