Preferred Label : deoxyribonuclease i;
MeSH definition : An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester
linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic
cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme
has a preference for double-stranded DNA.;
MeSH synonym : dna endonuclease; endonuclease, dna; pancreatic dnase; dnase, pancreatic; dnase i; dnaase i; thymonuclease;
MeSH hyponym : dornavac;
Related MeSH term : T7-Endonuclease I; nickase; T4-Endonuclease II; streptodornase; DNA Nicking Enzyme; Endonuclease I; T4 Endonuclease II; T7 Endonuclease I;
Registry Number MeSH : EC 3.1.21.1;
MeSH annotation : do not confuse X ref STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE: see note
there; DF: note short X ref; do not confuse entry term STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE;
Is substance : O;
UNII : EC 3.1.21.1;
Origin ID : D003850;
UMLS CUI : C0011519;
Allowable qualifiers
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Indexing information
- distel [MeSH Supplementary Concept]
Record concept(s)
Related MeSH Supplementary Concept(s)
See also inter- (CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to NTBT
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester
linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic
cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme
has a preference for double-stranded DNA.
https://www.cochrane.org/fr/CD001127/CF_la-dornase-alfa-un-medicament-inhale-dans-le-traitement-des-maladies-pulmonaires-chez-les-personnes
2021
false
true
false
France
United Kingdom
lung diseases
recombinant proteins
deoxyribonuclease i
treatment outcome
review of literature
french abstract
dornase alfa
cystic fibrosis
---
https://www.cochrane.org/fr/CD007923/CF_determination-du-moment-de-linhalation-de-la-dornase-alfa-chez-les-personnes-atteintes-de
2021
false
true
false
France
United Kingdom
dornase alfa
deoxyribonuclease i
treatment outcome
review of literature
french abstract
cystic fibrosis
administration, inhalation
deoxyribonuclease i
recombinant proteins
---
http://www.has-sante.fr/portail/jcms/c_1036527/pulmozyme
http://www.has-sante.fr/portail/upload/docs/application/pdf/2011-04/pulmozyme_-_ct-_7639.pdf
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-11/pulmozyme_ct_7639.pdf
http://www.has-sante.fr/portail/jcms/c_601731/pulmozyme-sortie-de-la-reserve-hospitaliere-decret-2004
2011
France
French
deoxyribonuclease i
cystic fibrosis
nebulizers and vaporizers
administration, inhalation
child
adult
deoxyribonuclease i
cystic fibrosis
DNASE1 protein, human
dornase alfa (desoxyribonuclease)
deoxyribonuclease i
dornase alfa
airway obstruction
guidelines for drug use
---
http://www.lecrat.eu/?s=Dornase+alfa
2009
France
French
pregnancy
deoxyribonuclease i
expectorants
DNASE1 protein, human
dornase alfa (desoxyribonuclease)
deoxyribonuclease i
dornase alfa
drug information
---
http://www.meddispar.fr/medicaments/3646754
2008
France
French
administration, inhalation
deoxyribonuclease i
nebulizers and vaporizers
drug prescriptions
legislation, drug
DNASE1 protein, human
dornase alfa (desoxyribonuclease)
dornase alfa
drug information
---