deoxyribonuclease i

Preferred Label : deoxyribonuclease i;

MeSH definition : An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.;

MeSH synonym : dna endonuclease; endonuclease, dna; pancreatic dnase; dnase, pancreatic; dnase i; dnaase i; thymonuclease;

MeSH hyponym : dornavac;

Related MeSH term : T7-Endonuclease I; nickase; T4-Endonuclease II; streptodornase; DNA Nicking Enzyme; Endonuclease I; T4 Endonuclease II; T7 Endonuclease I;

Registry Number MeSH : EC 3.1.21.1;

MeSH annotation : do not confuse X ref STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE: see note there; DF: note short X ref; do not confuse entry term STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE;

Is substance : O;

UNII : EC 3.1.21.1;

Details

Origin ID

D003850;

UMLS CUI

C0011519;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Deoxyribonuclease I [OMIM gene]
- Product containing streptodornase (medicinal product) [SNOMED CT concept]
- Streptodornase [ICD-11 Extension code]
- Streptodornase [NCIt concept]
- Streptodornase [ICHI extension code]
- Streptodornase (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Deoxyribonuclease I (substance) [SNOMED CT concept]
- deoxyribonuclease i [SNOMED Notion]
Indexing information
- Imds-60 protein, mouse [MeSH Supplementary Concept]
- distel [MeSH Supplementary Concept]
Record concept(s)
- T4-Endonuclease II [MeSH concept]
- T7-Endonuclease I [MeSH concept]
- deoxyribonuclease I [MeSH concept]
- dornavac [MeSH concept]
- nickase [MeSH concept]
- streptodornase [MeSH concept]
Related MeSH Supplementary Concept(s)
- BspD6I protein, E coli [MeSH Supplementary Concept]
- DNASE1 protein, human [MeSH Supplementary Concept]
- DNASE1L1 protein, human [MeSH Supplementary Concept]
- DNASE1L2 protein, human [MeSH Supplementary Concept]
- DNASE1L3 protein, rat [MeSH Supplementary Concept]
- LINE-1 endonuclease, human [MeSH Supplementary Concept]
- Sda1 protein, streptococcus pyogenes [MeSH Supplementary Concept]
- dornase alfa [MeSH Supplementary Concept]
See also inter- (CISMeF)
- deoxyribonuclease I activity [GO term]
- deoxyribonuclease ii [SNOMED Notion]
- deoxyribonuclease v [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Deoxyribonuclease I (substance) [SNOMED CT concept]
- deoxyribonuclease i [SNOMED Notion]
Validated automatic mappings to NTBT
- Deoxyribonuclease [NCIt concept]
- Deoxyribonuclease (substance) [SNOMED CT concept]
- Product containing deoxyribonuclease (medicinal product) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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