MeSH definition : The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal
A-chain. It is a pancreatic peptide of about 31 residues, depending on the species.
Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released.
C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic
patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide
is 30 min, almost 8 times that of insulin.;
MeSH synonym : c peptide, proinsulin; connecting peptide; c-peptide, proinsulin; proinsulin c peptide; proinsulin c-peptide; C peptide;
MeSH annotation : from proinsulin only: not for peptide fragments from other proteins ( PEPTIDE FRAGMENTS);
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal
A-chain. It is a pancreatic peptide of about 31 residues, depending on the species.
Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released.
C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic
patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide
is 30 min, almost 8 times that of insulin.