MeSH definition : Endogenous glycoproteins from which SIALIC ACID has been removed by the action of
sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located
on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they
are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance
of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins.
They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.;
Endogenous glycoproteins from which SIALIC ACID has been removed by the action of
sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located
on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they
are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance
of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins.
They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.