" /> AIRE Protein - CISMeF





Preferred Label : AIRE Protein;

MeSH definition : A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.;

MeSH synonym : Protein, AIRE; Autoimmune Regulator Protein; Protein, Autoimmune Regulator; Regulator Protein, Autoimmune; Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein; APECED Protein; Protein, APECED;

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A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.

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04/05/2025


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