MeSH definition : A transcriptional regulator primarily expressed in medullary thymic epithelial cells.
It plays an important role in immunity by regulating the expression of a wide array
of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency
in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL
DYSTROPHY.;
A transcriptional regulator primarily expressed in medullary thymic epithelial cells.
It plays an important role in immunity by regulating the expression of a wide array
of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency
in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL
DYSTROPHY.