Polyether Polyketides

Preferred Label : Polyether Polyketides;

MeSH definition : Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.;

MeSH hyponym : Polyether Ionophores; Polyether Ionophore Antibiotics;

Details

Origin ID

D000095662;

UMLS CUI

C5828282;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- Marine Ladder Polyethers [MeSH concept]
- Polyether Antibiotics [MeSH concept]
- Polyether Polyketides [MeSH concept]
Related MeSH Supplementary Concept(s)
- 20-deoxysalinomycin [MeSH Supplementary Concept]
- A28086B [MeSH Supplementary Concept]
- X 14868A [MeSH Supplementary Concept]
- eribulin [MeSH Supplementary Concept]
- halichondrin A [MeSH Supplementary Concept]
- halichondrin B [MeSH Supplementary Concept]
- halichondrin C [MeSH Supplementary Concept]
- lonomycin C [MeSH Supplementary Concept]
- salinomycin [MeSH Supplementary Concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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