Preferred Label : Pradimicins and Benanomicins;
MeSH definition : Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone
skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria,
e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one
acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g.,
D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall
of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins
and benanomicins have anti-HIV activities.;
MeSH synonym : Pradimicin-Type Polyphenols; Pradimicin Type Polyphenols; Benanomicins and Pradimicins; Pradimicin-Like Polyketides; Pradimicin Like Polyketides;
MeSH hyponym : Benanomicins; Benanomicin and Pradimicin Antibiotics; Pradimicins;
Origin ID : D000095643;
UMLS CUI : C5828275;
Allowable qualifiers
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone
skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria,
e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one
acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g.,
D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall
of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins
and benanomicins have anti-HIV activities.
