RNA, Guide, CRISPR-Cas Systems

Preferred Label : RNA, Guide, CRISPR-Cas Systems;

MeSH definition : A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING.;

MeSH synonym : Guide RNA (CRISPR-Cas Systems); Guide RNA, CRISPR-Cas Systems; Guide RNA, CRISPR Cas Systems; RNA, Guide (CRISPR-Cas Systems);

MeSH hyponym : Guide RNA, CRISPR; CRISPR Guide RNA; crRNA; Guide RNA, Single; sgRNA (Single-Guide RNA); CRISPR-Cas Systems sgRNA (Single Guide RNA); Single-Guide RNA; RNA, Single-Guide; Single Guide RNA; sgRNA (CRISPR-Cas Systems); tracrRNA; Transactivating crRNA;

MeSH annotation : do not confuse with RNA, GUIDE, KINETOPLASTIDA; do not confuse sgRNA (SINGLE-GUIDE RNA) with sgRNA (SUBGENOMIC RNA);

Details

Origin ID

D000094704;

UMLS CUI

C5690826;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- RNA, CRISPR Guide [MeSH concept]
- RNA, Guide, CRISPR-Cas Systems [MeSH concept]
- RNA, Single Guide [MeSH concept]
- crRNA, Transactivating [MeSH concept]
See also
- CRISPR-Cas systems [MeSH Descriptor]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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