T-Cell Exhaustion

Preferred Label : T-Cell Exhaustion;

MeSH definition : Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions.;

MeSH synonym : Exhaustion, T-Cell; T Cell Exhaustion; T-Lymphocyte Exhaustion; Exhaustion, T-Lymphocyte; Exhaustions, T-Lymphocyte; T Lymphocyte Exhaustion; T-Lymphocyte Exhaustions;

Related MeSH term : Senescence, T-Cell; T Cell Senescence;

Details

Origin ID

D000094383;

UMLS CUI

C5690906;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Currated CISMeF NLP mapping
- Exhausted T-Cell [NCIt concept]
Record concept(s)
- T-Cell Exhaustion [MeSH concept]
See also
- T-Cell Senescence [MeSH Descriptor]
- lymphocyte depletion [MeSH Descriptor]
Semantic type(s)
- Pathologic Function [UMLS semantic type]
UMLS correspondences (same concept)
- exhausted T cell differentiation [GO term]

Keyword's position in hierarchy(ies) :

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