Tripeptidyl-Peptidase 1

Preferred Label : Tripeptidyl-Peptidase 1;

MeSH definition : Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVECEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.; Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.;

MeSH synonym : CLN2 Protein; Protein, CLN2; Tripeptidyl Peptidase I; Peptidase I, Tripeptidyl; Tripeptidyl Protease I; Tripeptidyl-Peptidase I; TPP1 Protein; Protein, TPP1; Tripeptidyl Aminopeptidase I;

CISMeF synonym : 1, Tripeptidyl-Peptidase; I, Tripeptidyl Peptidase; I, Tripeptidyl Protease; I, Tripeptidyl-Peptidase;

MeSH Related Number : EC 3.4.14.9;

Details

Origin ID

D000091346;

UMLS CUI

C0661884;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Tripeptidyl peptidase I [LOINC component]
- Tripeptidyl-peptidase I (substance) [SNOMED CT concept]
Record concept(s)
- Tripeptidyl-Peptidase 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- TPP1 protein, human [MeSH Supplementary Concept]
- Tpp1 protein, mouse [MeSH Supplementary Concept]
- Tpp1 protein, rat [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Tripeptidyl peptidase I [OMIM gene]
- tripeptidyl peptidase 1 [ORDO Gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Tripeptidyl peptidase I [LOINC component]
- Tripeptidyl-peptidase I (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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