Gamma Secretase Inhibitors and Modulators

Preferred Label : Gamma Secretase Inhibitors and Modulators;

MeSH definition : Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.;

MeSH synonym : GS Inhibitors and Modulators;

MeSH hyponym : Secretase Modulators, Gamma; GS Modulators; Secretase Inhibitors, Gamma; GS Inhibitors;

Details

Origin ID

D000091062;

UMLS CUI

C5544457;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- Gamma Secretase Inhibitors [MeSH concept]
- Gamma Secretase Inhibitors and Modulators [MeSH concept]
- Gamma Secretase Modulators [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- (1-(4-methyl-1-(6-(trifluoromethyl)-3-pyridinyl)pentyl)-2-(4-(trifluoromethyl)phenyl)-4-piperidinyl)acetic acid [MeSH Supplementary Concept]
- (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo(4,3-c)quinoline [MeSH Supplementary Concept]
- (S,E)-1-(2-methoxy-4-((4-(3,4,5-trifluorophenyl)-3,4,7,8-tetrahydropyrido(2,1-c)(1,2,4)oxadiazin-9(6H)-ylidene)methyl)phenyl)-4-methyl-1H-imidazol-3-ium-hemi-(E)-3-carboxyacrylate [MeSH Supplementary Concept]
- 1-((1,1,1-trifluoro-7-methyloctan-4-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid [MeSH Supplementary Concept]
- 1-(1-(4-fluorophenyl)ethyl)-3-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)methylene)-2-piperidinone [MeSH Supplementary Concept]
- 1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid [MeSH Supplementary Concept]
- 2',3',4',5,5',6,7,8,9,10-decahydro-2-(5-(4-fluorophenyl)-1-methylpyrazol-3-yl)-5'-(2,2,2-trifluoroethyl)spiro(6,9-methanobenzocycloocten-11,3'-(1,2,5)thiadiazole) 1',1'-dioxide [MeSH Supplementary Concept]
- 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide [MeSH Supplementary Concept]
- 2-(((3,5-difluorophenyl)acetyl)amino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)propanamide [MeSH Supplementary Concept]
- 2-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-(3-methyl-4-oxo-4,5-dihydro-3H-benzo(d)(1,2)diazepin-5-yl)propanamide [MeSH Supplementary Concept]
- 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide [MeSH Supplementary Concept]
- 2-(3,5-bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid [MeSH Supplementary Concept]
- 2-(3-(3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl) -8-(3,4,5-trifluorophenoxy)-5,6,7,8-tetrahydro(1,2,4)triazolo(4,3-a)pyridin-8-yl)propan-2-ol [MeSH Supplementary Concept]
- 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-3-cyclobutylpropanoic acid [MeSH Supplementary Concept]
- 2-(N-((3-(1,2,4-oxadiazol-3-yl)bicyclo(1.1.1)pentan-1-yl)methyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide [MeSH Supplementary Concept]
- 24-diamino-5-phenylthiazole [MeSH Supplementary Concept]
- 3-((cyclohexylmethyl)(3,3-dimethylbutyl)amino)-2-(4-(trifluoromethyl)phenyl)cyclohexyl)acetic acid [MeSH Supplementary Concept]
- 3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)butyramide [MeSH Supplementary Concept]
- 3-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid [MeSH Supplementary Concept]
- 4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo(4,3-c)quinoline [MeSH Supplementary Concept]
- 7-(4-fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-6,7-dihydro-5H-cyclopenta(d)pyrimidine-2,4-diamine [MeSH Supplementary Concept]
- AZ1136 [MeSH Supplementary Concept]
- AZ3303 [MeSH Supplementary Concept]
- AZ4800 [MeSH Supplementary Concept]
- BIIB042 [MeSH Supplementary Concept]
- BMS 708163 [MeSH Supplementary Concept]
- BMS-986115 [MeSH Supplementary Concept]
- BPN-15606 [MeSH Supplementary Concept]
- ELN594 [MeSH Supplementary Concept]
- FRM-36143 [MeSH Supplementary Concept]
- L 685458 [MeSH Supplementary Concept]
- LY900009 [MeSH Supplementary Concept]
- MRK 003 [MeSH Supplementary Concept]
- MRK 560 [MeSH Supplementary Concept]
- MW167 [MeSH Supplementary Concept]
- N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester [MeSH Supplementary Concept]
- N-(N-(3,5-difluorophenylacetyl)alanyl)phenylglycine 4-benzoylbenzyl amide [MeSH Supplementary Concept]
- N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide [MeSH Supplementary Concept]
- SCH 1500022 [MeSH Supplementary Concept]
- SCH 900229 [MeSH Supplementary Concept]
- SPI-1865 [MeSH Supplementary Concept]
- begacestat [MeSH Supplementary Concept]
- benzyloxycarbonyl-isoleucyl-leucinal [MeSH Supplementary Concept]
- benzyloxycarbonyl-leucyl-leucyl-norleucinal [MeSH Supplementary Concept]
- curcumin-phenylalanine [MeSH Supplementary Concept]
- curcumin-valine [MeSH Supplementary Concept]
- cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate [MeSH Supplementary Concept]
- dibenzazepine [MeSH Supplementary Concept]
- nirogacestat [MeSH Supplementary Concept]
- tarenflurbil [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- Gamma-Secretase Inhibitor [NCIt concept]

Keyword's position in hierarchy(ies) :

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