Preferred Label : Senescence-Associated Secretory Phenotype;
MeSH definition : A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated
secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor
enriched SECRETOME of many types of senescent cells which leads to tissue repair or
tissue and organ damage over time and links SASP to age-related disorders.;
Définition CISMeF : Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent
cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators,
growth factors, and proteases. SASP may also consist of exosomes and ectosomes containing
enzymes, microRNA, DNA fragments, chemokines, and other bioactive factors. Initially,
SASP is immunosuppressive (characterized by TGF-β1 and TGF-β3) and profibrotic, but
progresses to become proinflammatory (characterized by IL-1β, IL-6 and IL-8) and fibrolytic.
SASP is the primary cause of the detrimental effects of senescent cells (source https://en.wikipedia.org/wiki/Senescence-associated_secretory_phenotype).;
MeSH synonym : Phenotype, Senescence-Associated Secretory; Secretory Phenotype, Senescence-Associated; Senescence Associated Secretory Phenotype; Senescent Cell SASP; SASP, Senescent Cell; SASPs, Senescent Cell; Senescent Cell SASPs;
CISMeF acronym : SASP;
Origin ID : D000089262;
UMLS CUI : C4505466;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Semantic type(s)
A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated
secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor
enriched SECRETOME of many types of senescent cells which leads to tissue repair or
tissue and organ damage over time and links SASP to age-related disorders.
Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent
cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators,
growth factors, and proteases. SASP may also consist of exosomes and ectosomes containing
enzymes, microRNA, DNA fragments, chemokines, and other bioactive factors. Initially,
SASP is immunosuppressive (characterized by TGF-β1 and TGF-β3) and profibrotic, but
progresses to become proinflammatory (characterized by IL-1β, IL-6 and IL-8) and fibrolytic.
SASP is the primary cause of the detrimental effects of senescent cells (source https://en.wikipedia.org/wiki/Senescence-associated_secretory_phenotype).
