Preferred Label : Centromere Protein A;
MeSH definition : A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar
to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within
the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical
role in recruiting kinetochore proteins and progression through MITOSIS, chromosome
segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like
AUTOIMMUNE DISEASES.;
MeSH synonym : CENPA Protein; Centromere Protein 17K; CENP-A Protein; CENP A Protein; Centromere Autoantigens 17K; Autoantigens 17K, Centromere;
Origin ID : D000076247;
UMLS CUI : C0055062;
- Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar
to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within
the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical
role in recruiting kinetochore proteins and progression through MITOSIS, chromosome
segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like
AUTOIMMUNE DISEASES.