Centromere Protein A

Preferred Label : Centromere Protein A;

MeSH definition : A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.;

MeSH synonym : CENPA Protein; Centromere Protein 17K; CENP-A Protein; CENP A Protein; Centromere Autoantigens 17K; Autoantigens 17K, Centromere;

Details

Origin ID

D000076247;

UMLS CUI

C0055062;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CENPA Gene [NCIt concept]
- Centromeric protein a [OMIM gene]
- Histone H3-Like Centromeric Protein A [NCIt concept]
- centromere protein A [HGNC gene]
Currated CISMeF NLP mapping
- Centromere protein A [LOINC component]
Indexing information
- anticentromere antibody [MeSH Supplementary Concept]
Record concept(s)
- centromere protein A [MeSH concept]
Related MeSH Supplementary Concept(s)
- CENPA protein, human [MeSH Supplementary Concept]
- Cenpa protein, mouse [MeSH Supplementary Concept]
- cid protein, drosophila [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Centromere protein A [LOINC component]

Keyword's position in hierarchy(ies) :

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