MeSH definition : A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the
CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes
that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic
cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK
gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role
as an inhibitor of TOLL-LIKE RECEPTORS signaling.;
MeSH synonym : Kinase, c-Mer Tyrosine; Tyrosine Kinase, c-Mer; c Mer Tyrosine Kinase; c-Mer Proto-Oncogene Tyrosine Kinase; c Mer Proto Oncogene Tyrosine Kinase; MERTK;
A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the
CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes
that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic
cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK
gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role
as an inhibitor of TOLL-LIKE RECEPTORS signaling.