Fanconi Anemia Complementation Group N Protein - CISMeF
Fanconi Anemia Complementation Group N ProteinMeSH Descriptor
Preferred Label : Fanconi Anemia Complementation Group N Protein;
MeSH definition : A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding
region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS
RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE;
and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize
these proteins at homologous recombination sites. Mutations in the PALB2 gene are
associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS;
and susceptibility to BREAST CANCER.;
MeSH synonym : FANCN Protein; PALB2 Protein; Partner and Localizer of BRCA2 Protein;
A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding
region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS
RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE;
and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize
these proteins at homologous recombination sites. Mutations in the PALB2 gene are
associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS;
and susceptibility to BREAST CANCER.