NEDD8 Protein - CISMeF

Preferred Label : NEDD8 Protein;

MeSH definition : A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins;

MeSH synonym : Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8; Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8; NEDD-8 Protein; NEDD 8 Protein; Ubiquitin-like Protein NEDD8; NEDD8, Ubiquitin-like Protein; Ubiquitin like Protein NEDD8;

Details

Origin ID

D000075687;

UMLS CUI

C4318623;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- NEDD8 Protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- NED-8 protein, C elegans [MeSH Supplementary Concept]
- NEDD8 protein, human [MeSH Supplementary Concept]
- Nedd8 protein, drosophila [MeSH Supplementary Concept]
- Nedd8 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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