MeSH definition : A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2
domains and six membrane proximal (C-terminal) fibronectin type III domains. It is
expressed primarily in the nerve axons and differentiated intestinal cells and is
required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however,
it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor.
DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC
gene are observed in tumor metastases and the protein is not expressed in undifferentiated
COLORECTAL CARCINOMA cells.;
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2
domains and six membrane proximal (C-terminal) fibronectin type III domains. It is
expressed primarily in the nerve axons and differentiated intestinal cells and is
required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however,
it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor.
DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC
gene are observed in tumor metastases and the protein is not expressed in undifferentiated
COLORECTAL CARCINOMA cells.