MeSH definition : A family of transmembrane proteins that function primarily as calcium-activated chloride
channels. Structurally, they form a homodimer where each subunit consists of eight
transmembrane helices with the N and C terminals exposed to the cytosol. The regions
between helices 5 and 7 may be important for ion pore formation and calcium ion binding.;
MeSH synonym : Anoctamin; TMEM16 Protein Family; Protein Family, TMEM16; TMEM16 Proteins;
A family of transmembrane proteins that function primarily as calcium-activated chloride
channels. Structurally, they form a homodimer where each subunit consists of eight
transmembrane helices with the N and C terminals exposed to the cytosol. The regions
between helices 5 and 7 may be important for ion pore formation and calcium ion binding.