MeSH definition : A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN)
at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding
transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to
repress expression of genes involved in cell growth and differentiation such as MATRIX
METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and
CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia
patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical
role in leukemogenesis.;
MeSH synonym : Eight Twenty One Protein; RUNX1T1 Protein;
A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN)
at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding
transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to
repress expression of genes involved in cell growth and differentiation such as MATRIX
METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and
CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia
patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical
role in leukemogenesis.
Allowable qualifiers