Pre-B-Cell Leukemia Transcription Factor 1

Preferred Label : Pre-B-Cell Leukemia Transcription Factor 1;

MeSH definition : A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.;

MeSH synonym : Pre B Cell Leukemia Transcription Factor 1; PBX1 Homeobox Protein; Homeobox Protein, PBX1; Pre-B-Cell Leukemia Homeobox 1 Protein; Pre B Cell Leukemia Homeobox 1 Protein;

Détails

Origin ID

D000075062;

UMLS CUI

C4319766;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Pre-B-Cell Leukemia Transcription Factor 1 [NCIt concept]
- Pre-b-cell leukemia transcription factor 1 [OMIM gene]
Record concept(s)
- Pre-B-Cell Leukemia Transcription Factor 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- Pbx1 protein, mouse [MeSH Supplementary Concept]
- pbx1 protein, human [MeSH Supplementary Concept]
- pbx1a protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

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