MeSH definition : A forkhead box transcription factor that is expressed in the developing eyelid and
during very early development of the gonad, prior to sex determination. It is essential
for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation
to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene
are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian
failure).;
A forkhead box transcription factor that is expressed in the developing eyelid and
during very early development of the gonad, prior to sex determination. It is essential
for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation
to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene
are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian
failure).