Aldo-Keto Reductase Family 1 Member C2

Preferred Label : Aldo-Keto Reductase Family 1 Member C2;

MeSH definition : Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 46, XY DISORDERS OF SEX DEVELOPMENT (SRXY8).; Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).;

MeSH synonym : Aldo Keto Reductase Family 1 Member C2; Dihydrodiol Dehydrogenase-Bile Acid Binding Protein; Dihydrodiol Dehydrogenase Bile Acid Binding Protein; AKR1C2 Protein; Dihydrodiol Dehydrogenase 2;

Registry Number MeSH : EC 1.1.1.357;

UNII : EC 1.1.1.357;

Details

Origin ID

D000074422;

UMLS CUI

C4319743;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- AKR1C2 Gene [NCIt concept]
- Aldo-Keto Reductase Family 1 Member C2 [NCIt concept]
- Aldo-keto reductase family 1, member c2 [OMIM gene]
- aldo-keto reductase family 1 member C2 [ORDO Gene]
- aldo-keto reductase family 1 member C2 [HGNC gene]
Record concept(s)
- Aldo-Keto Reductase Family 1 Member C2 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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