Valosin Containing Protein

Preferred Label : Valosin Containing Protein;

MeSH definition : A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.;

MeSH synonym : Cell Cycle Protein CDC48; Valosine-Containing Protein; Valosine Containing Protein; p97 Valosin-Containing Protein; Valosin-Containing Protein, p97; p97 Valosin Containing Protein; Valosin-Containing Protein; CDC48 Protein; Cell Cycle Protein CDC48p;

Registry Number MeSH : EC 3.6.4.6;

UNII : EC 3.6.4.6;

Details

Origin ID

D000074405;

UMLS CUI

C1314889;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Transitional Endoplasmic Reticulum ATPase [NCIt concept]
- Valosin-containing protein [OMIM gene]
- valosin containing protein [ORDO Gene]
- valosin containing protein [HGNC gene]
Record concept(s)
- Valosin Containing Protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- CDC48 protein, S cerevisiae [MeSH Supplementary Concept]
- VCP protein, human [MeSH Supplementary Concept]
- VCP protein, trypanosoma brucei [MeSH Supplementary Concept]
- Vcp protein, Glycine max [MeSH Supplementary Concept]
- Vcp protein, mouse [MeSH Supplementary Concept]
- Vcp protein, rat [MeSH Supplementary Concept]
- cdc-48.1 protein, C elegans [MeSH Supplementary Concept]
- ter94 protein, Drosophila [MeSH Supplementary Concept]
- vat protein, thermoplasma acidophilum [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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