High-Temperature Requirement A Serine Peptidase 1 - CISMeF
High-Temperature Requirement A Serine Peptidase 1MeSH Descriptor
Preferred Label : High-Temperature Requirement A Serine Peptidase 1;
MeSH definition : A secreted serine protease that contains a Kazal domain-like region and a C-terminal
PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS;
PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1
gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal
Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).;
MeSH synonym : High Temperature Requirement A Serine Peptidase 1; Serine Protease HTRA1; HTRA1, Serine Protease; Protease HTRA1, Serine;
A secreted serine protease that contains a Kazal domain-like region and a C-terminal
PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS;
PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1
gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal
Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).