Preferred Label : TRPC6 Cation Channel;
MeSH definition : A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS
and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed
in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES
in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL
GLOMERULOSCLEROSIS type 2.;
MeSH synonym : Cation Channel, TRPC6; Channel, TRPC6 Cation; Transient Receptor Potential Cation Channel Subfamily C, Member 6; TRPC6;
Origin ID : D000074287;
UMLS CUI : C4319829;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS
and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed
in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES
in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL
GLOMERULOSCLEROSIS type 2.
