" /> Transcription Factor 4 - CISMeF





Preferred Label : Transcription Factor 4;

MeSH definition : A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.;

MeSH synonym : TCF4 Transcription Factor; Transcription Factor, TCF4; TCF-4 Transcription Factor; TCF 4 Transcription Factor; Transcription Factor, TCF-4; TCF-4 Protein; TCF 4 Protein;

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A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.

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27/07/2025


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