Transcription Factor 4

Preferred Label : Transcription Factor 4;

MeSH definition : A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.;

MeSH synonym : TCF4 Transcription Factor; Transcription Factor, TCF4; TCF-4 Transcription Factor; TCF 4 Transcription Factor; Transcription Factor, TCF-4; TCF-4 Protein; TCF 4 Protein;

Détails

Origin ID

D000073940;

UMLS CUI

C4319769;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Transcription Factor 4 [NCIt concept]
- Transcription factor 4 [OMIM gene]
- transcription factor 4 [ORDO Gene]
- transcription factor 4 [HGNC gene]
Record concept(s)
- Transcription Factor 4 [MeSH concept]
Related MeSH Supplementary Concept(s)
- TCF4 protein, human [MeSH Supplementary Concept]
- Tcf4 protein, mouse [MeSH Supplementary Concept]
- Tcf4 protein, rat [MeSH Supplementary Concept]
- Tcf4 protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Position du mot-clé dans l'(les) arborescence(s) :

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