MeSH definition : A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal
CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates
transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3'
sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome,
a severe developmental disorder.;
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal
CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates
transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3'
sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome,
a severe developmental disorder.