MeSH definition : A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they
function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN
PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds
to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to
the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION
and establishing CELL POLARITY.;
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they
function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN
PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds
to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to
the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION
and establishing CELL POLARITY.
Allowable qualifiers