Preferred Label : Homer Scaffolding Proteins;
MeSH definition : Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1,
Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis,
whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells.
Homer proteins are best known as scaffold proteins at the post-synaptic density where
they facilitate synaptic signaling. They function as a molecular switch in metabotropic
glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.;
MeSH synonym : Proteins, Homer Scaffolding; Scaffolding Proteins, Homer; Homer Proteins; Proteins, Homer; Homer Protein; Protein, Homer;
DeCS synonym : Homer 2; Homer 3; Homer 1; Homer 1a; Homer 1C;
MeSH hyponym : Homer 1C Proteins; Proteins, Homer 1C; Homer 3 Proteins; Proteins, Homer 3; Homer 2 Proteins; Proteins, Homer 2; Homer 1 Proteins; Proteins, Homer 1;
Origin ID : D000072233;
UMLS CUI : C0537022;
Allowable qualifiers
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1,
Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis,
whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells.
Homer proteins are best known as scaffold proteins at the post-synaptic density where
they facilitate synaptic signaling. They function as a molecular switch in metabotropic
glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
