Preferred Label : AC133 Antigen;
MeSH definition : A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring
as several isoforms produced by alternative splicing which are processed into mature
forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic
stem cells and CD34 positive leukemias. Functionally, it is associated with roles
in cell differentiation, proliferation, and apoptosis. Specifically, it regulates
the organization of apical plasma membrane in epithelial cells, disk morphogenesis
during early retinal development, MAPK and Akt signaling pathways, and in cholesterol
metabolism.;
MeSH synonym : Antigen, AC133; CD133 Antigen; Antigen, CD133; PROML1; Prominin; Prominin-1; Prominin 1; Prominin-Like PROML1; Prominin Like PROML1; AC133-1 Antigen; AC133 1 Antigen; Antigen, AC133-1; Fudenine;
CISMeF synonym : PROML1, Prominin-Like;
DeCS synonym : AC133-2 Antigen; AC141 Antigen;
MeSH hyponym : Antigen, AC141; AC133 2 Antigen; Antigen, AC133-2;
Wikipedia link : https://en.wikipedia.org/wiki/Prominin 1;
Origin ID : D000071916;
UMLS CUI : C0673028;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring
as several isoforms produced by alternative splicing which are processed into mature
forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic
stem cells and CD34 positive leukemias. Functionally, it is associated with roles
in cell differentiation, proliferation, and apoptosis. Specifically, it regulates
the organization of apical plasma membrane in epithelial cells, disk morphogenesis
during early retinal development, MAPK and Akt signaling pathways, and in cholesterol
metabolism.
