Checkpoint Kinase 1

Preferred Label : Checkpoint Kinase 1;

MeSH definition : A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.;

MeSH synonym : Chk1 Kinase; Chk1 Protein Kinase; Protein Kinase, Chk1; Checkpoint-1 Kinase;

Registry Number MeSH : EC 2.7.11.1;

UNII : EC 2.7.11.1;

Details

Origin ID

D000071877;

UMLS CUI

C0216510;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Checkpoint kinase 1 [OMIM gene]
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]
- checkpoint kinase 1 [HGNC gene]
Record concept(s)
- checkpoint kinase 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CHEK1 protein, human [MeSH Supplementary Concept]
- Chek1 protein, Xenopus [MeSH Supplementary Concept]
- Chek1 protein, mouse [MeSH Supplementary Concept]
- Chek1 protein, rat [MeSH Supplementary Concept]
- Chk1 protein, S pombe [MeSH Supplementary Concept]
- chk-1 protein, C elegans [MeSH Supplementary Concept]
- grp protein, Drosophila [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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