Tumor Suppressor p53-Binding Protein 1

Preferred Label : Tumor Suppressor p53-Binding Protein 1;

MeSH definition : A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.;

MeSH synonym : Tumor Suppressor p53 Binding Protein 1; TP53BP1 Protein; p202 Protein; Tumor Protein p53-Binding Protein, 1; Tumor Protein p53 Binding Protein, 1; 53BP1 Protein;

Details

Origin ID

D000071857;

UMLS CUI

C2982393;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
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- contraindications [MeSH Qualifier]
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- drug effects [MeSH Qualifier]
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- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
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- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- TP53-Binding Protein 1 [NCIt concept]
- Tumor protein p53-binding protein 1 [OMIM gene]
- tumor protein p53 binding protein 1 [HGNC gene]
Record concept(s)
- Tumor Suppressor p53-Binding Protein 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- TP53BP1 protein, human [MeSH Supplementary Concept]
- Trp53bp1 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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