Preferred Label : Soluble Guanylyl Cyclase;
MeSH definition : A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit
consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain,
and a C-terminal catalytic domain. All four domains are homologous proteins with a
similar conformation of functional domains. Soluble guanylate cyclase catalyzes the
formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling
pathway involved in the regulation of a variety of biological and physiological processes
in mammals.;
MeSH synonym : Cyclase, Soluble Guanylyl; Guanylyl Cyclase, Soluble; Receptor, Nitric Oxide; Nitric Oxide-Sensitive Guanylyl Cyclase; Nitric Oxide Sensitive Guanylyl Cyclase; Nitric Oxide Receptor; Oxide Receptor, Nitric; Nitric Oxide Receptors; Oxide Receptors, Nitric; Cyclase, Soluble Guanylate; Guanylate Cyclase, Soluble; Soluble Guanylate Cyclase;
CISMeF synonym : Receptors, Nitric Oxide;
DeCS synonym : Soluble Guanylyl Cyclase, alpha Subunit; Soluble Guanylyl Cyclase, beta Subunit;
MeSH Related Number : EC 4.6.1.2;
Registry Number MeSH : EC 4.6.1.2;
Wikipedia link : https://en.wikipedia.org/wiki/Soluble guanylyl cyclase;
UNII : EC 4.6.1.2;
Origin ID : D000071756;
UMLS CUI : C1097411;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit
consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain,
and a C-terminal catalytic domain. All four domains are homologous proteins with a
similar conformation of functional domains. Soluble guanylate cyclase catalyzes the
formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling
pathway involved in the regulation of a variety of biological and physiological processes
in mammals.
