Werner Syndrome Helicase

Preferred Label : Werner Syndrome Helicase;

MeSH definition : A DNA-dependent helicase and 3'-5' exonuclease. It has 3'- 5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.;

MeSH synonym : Helicase, Werner Syndrome; Werner Syndrome ATP-Dependent Helicase; Werner Syndrome ATP Dependent Helicase; RECQL2 Protein; Werner Syndrome RecQ-Like Helicase; Werner Syndrome RecQ Like Helicase; RECQ3 Protein;

Registry Number MeSH : EC 3.6.4.12;

Wikipedia link : https://en.wikipedia.org/wiki/Werner syndrome helicase;

UNII : EC 3.6.4.12;

Details

Origin ID

D000071657;

UMLS CUI

C4255267;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Werner Syndrome ATP-Dependent Helicase [NCIt concept]
Record concept(s)
- Werner Syndrome Helicase [MeSH concept]
Related MeSH Supplementary Concept(s)
- WRN protein, human [MeSH Supplementary Concept]
- WRN protein, rat [MeSH Supplementary Concept]
- WRN protein, xenopus [MeSH Supplementary Concept]
- wrn protein, mouse [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- werner syndrome [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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