MeSH definition : Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs)
and may also function independently of GPCR signaling. They bind and recruit many
different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES;
and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors
to determine the specificity of the cellular response to signaling.;
Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs)
and may also function independently of GPCR signaling. They bind and recruit many
different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES;
and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors
to determine the specificity of the cellular response to signaling.
Allowable qualifiers