APOBEC-3G Deaminase

Preferred Label : APOBEC-3G Deaminase;

MeSH definition : An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.;

MeSH synonym : APOBEC 3G Deaminase; Deaminase, APOBEC-3G; APOBEC-Related Cytidine Deaminase; APOBEC Related Cytidine Deaminase; Cytidine Deaminase, APOBEC-Related; APOBEC3G Protein; CEM15 Protein; APOBEC3G Deaminase; Deaminase, APOBEC3G; APOBEC-3G Protein; APOBEC 3G Protein; APOBEC-Related Protein; APOBEC Related Protein; APOBEC-3G dC-dU Editing Enzyme; APOBEC 3G dC dU Editing Enzyme;

Registry Number MeSH : EC 3.5.4.5;

UNII : EC 3.5.4.5;

Details

Origin ID

D000071480;

UMLS CUI

C4255227;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- DNA dC to dU-Editing Enzyme APOBEC-3G [NCIt concept]
Record concept(s)
- APOBEC-3G Deaminase [MeSH concept]
Related MeSH Supplementary Concept(s)
- APOBEC3G protein, human [MeSH Supplementary Concept]
- APOBEC3G protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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