DEAD Box Protein 58

Preferred Label : DEAD Box Protein 58;

MeSH definition : A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).;

MeSH synonym : DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58; Probable ATP-Dependent RNA Helicase DDX58; Probable ATP Dependent RNA Helicase DDX58; RIG-I-like Receptor 1; RIG I like Receptor 1;

Registry Number MeSH : EC 3.6.4.13;

UNII : EC 3.6.4.13;

Details

Origin ID

D000071457;

UMLS CUI

C4255173;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Antiviral Innate Immune Response Receptor RIG-I [NCIt concept]
- DEAD Box Protein 58 Measurement [NCIt concept]
Record concept(s)
- DEAD Box Protein 58 [MeSH concept]
Related MeSH Supplementary Concept(s)
- Ddx58 protein, mouse [MeSH Supplementary Concept]
- Ddx58 protein, rat [MeSH Supplementary Concept]
- RIGI protein, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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